Introducing the
CRISPR Cascade™
The CRISPR Cascade™ enables an unprecedented combination of speed and multiplexing capabilities, enabling ultra-rapid, accurate results in a highly re-programmable format.
CRISPR Cascade™
Unlocking the true power of CRISPR for molecular detection
Our breakthrough platform enables ultra-rapid molecular detection of highly multiplexed analytes, setting a new standard for accuracy without the need for target amplification. With our cutting-edge technology, we are unlocking a universe of possibilities in molecular biology.
Target amplification-free molecular detection
The combined use of multiple CRISPR enzymes, blocked nucleic acid sequences, and reporter molecules generates robust signal without the need for target amplification.
Massive multiplexing
capability
Unlike PCR or other DNA/RNA amplification technologies, the CRISPR Cascade removes several fundamental constraints, enabling incredibly simple, highly multiplexed assays, in pooled and spatial formats, without signal loss or cross reactivity issues.
Rapid reprogramming
for new targets
With a generally applicable signal amplification for DNA or RNA, rapid product development can be achieved with simple target sequence selection and optimization.
CRISPR Cascade™
How It Works
STEP 1:
Target Identification
The CRISPR Cascade™ operates at unprecedented speed and processing power, enabling near instantaneous results with best-in-class accuracy. This is achieved by utilizing two ribonucleoproteins (RNPs), the first (RNP1) to identify the target sequence of interest while initiating the detection signal, while the second (RNP2) to specifically amplify the signal.
Step 3:
RNP2 Formation & Triggering the Cascade
Once the RNP2 blocked target is cleaved, the freed target and RNP2 Cas enzyme bind to generate a RNP2 complex. Similar to RNP1 complex function, activated RNP2 complex will start cleavage activity of both eporter molecules and additional blocked RNP2 targets. This generates a specific signal amplification of the original RNP1 activity.
CRISPR Cascade™
One platform.
Nearly endless applications.
The CRISPR Cascade™ offers a novel platform with vast application potential for molecular detection and editing use cases. Our mission is to apply the power of the CRISPR Cascade™ to deliver impactful, high value solutions in diagnostics, therapeutics, research, and other applications. Stay tuned for updates in the coming months as we share details on our applications focus and scientific data.
Therapeutics
Diagnostics
Research Tools
Frequently Asked Questions
Find answers to common questions about our breakthrough molecular detection platform.
How does it work?
Our platform utilizes advanced molecular biology techniques to detect highly multiplexed analytes with unparalleled accuracy. It eliminates the need for target amplification, providing near-instant results.
What are the benefits?
Our technology offers best-in-class accuracy, rapid detection, and the ability to analyze multiple analytes simultaneously. It revolutionizes molecular biology research and diagnostics.
Is it compatible with existing lab equipment?
Yes, our platform is designed to be compatible with standard lab equipment, making it easy to integrate into existing workflows without the need for significant changes.
What industries can benefit?
Our technology has applications in various industries, including healthcare, pharmaceuticals, agriculture, and environmental monitoring. It enables faster and more accurate analysis.
Is it cost-effective?
Absolutely. Our platform offers a cost-effective solution for molecular detection, reducing the need for expensive reagents and amplification processes.
Interested in learning more?
Contact us to learn how the CRISPR Cascade™ Platform and our industry-leading discovery and development expertise opens up a universe of application potential.